Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw
Pillow ODM design company in Vietnam
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Soft-touch pillow OEM service in Indonesia
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia graphene sports insole ODM
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene sheet OEM supplier Taiwan
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ESG-compliant OEM manufacturer in Taiwan
Examples of the diversity of species of free-living rove beetles. Credit: J. Parker Beetles are an evolutionary success, with rove beetles’ diversification largely due to their unique tergal gland that synthesizes defensive chemicals. This adaptation, evolving over millions of years, has allowed them to occupy diverse ecological niches, underlining the impact of cellular changes on species evolution. Evolutionary Mysteries and Beetle Diversity As life on Earth evolved, some groups of organisms became incredibly diverse, while others remained relatively limited—or even disappeared entirely. Understanding why evolution favored certain groups over others has been a key question for scientists studying the history of life. Beetles are a prime example of evolutionary success. With about 400,000 known species—roughly a quarter of all described life forms—and countless more likely undiscovered, their diversity is unmatched. Their beauty and variety captivated a young Charles Darwin and intrigued Alfred Russell Wallace, both co-discoverers of natural selection. But what makes beetles so prolific? One popular explanation is their evolution of elytra—hardened, shield-like structures that protect their delicate flight wings. This adaptation allows beetles to thrive in environments inaccessible to many other insects. Another theory suggests that beetles co-evolved with flowering plants, diversifying alongside them as they adapted to feed on these plants. Joe Parker’s decades-long fascination with bugs and beetles led to his recent appointment as an assistant professor at Caltech. As an entomologist, he studies particular species of beetle that can help us answer some of the fundamental questions of evolution. The Unique Traits of Rove Beetles Yet, both these ideas fall short in explaining the biggest beetle group of all—the rove beetles (Staphylinidae) a sprawling radiation of over 66,000 species—not just the largest beetle family, but the largest family in the entire animal kingdom. Rove beetles are an enigma: they seem to have both forsaken strongly protective elytra and are mostly predatory instead of feeding on plants. Yet, they exploded across Earth’s biosphere, invading every terrestrial niche imaginable over the past 200 million years. What drove this remarkable success is the focus of a new study by researchers in the laboratory of Joe Parker, assistant professor of biology and biological engineering, Chen Scholar, and director of Caltech’s Center for Evolutionary Science. Led by former postdoctoral scholar Sheila Kitchen, the study, appearing online on June 17 in the journal Cell, pinpoints evolution of two cell types that form a chemical defense gland within these beetles’ bodies as a catalyst behind their global radiation. An ant faces off against a rove beetle. Credit: Taku Shimada The Power of the Tergal Gland In 2021, researchers in the Parker lab studied a gland in rove beetles called the “tergal gland,” a structure at the tip of their flexible abdomens. The team showed how the tergal gland is made up of two unique cell types: one that makes toxic compounds called benzoquinones, and another that makes a liquid mixture (or solvent) into which the benzoquinones dissolve, creating a potent cocktail that the beetle discharges at predators. In the new work, Kitchen, Parker and their collaborators assembled whole genomes from a diverse set of species spanning the rove beetle evolutionary tree, and analyzed the genes expressed with the gland’s two cell types. Doing so enabled them to uncover an ancient genetic toolkit that evolved over 100 million years ago, equipping these insects with their powerful chemical defenses. “In piecing together the genomes, we were amazed by how similar the genetic architecture of the gland was across this massive group of beetles,” says Kitchen, who is now an assistant professor at Texas A&M University. “It was when we started to look at specific gene families, we found hundreds of ancient genes that had found new functions within the gland, and a small but essential set of evolutionarily new genes. These new genes were key to rove beetles evolving their amazing chemistry. Telling this story was made possible by our fantastic interdisciplinary team of evolutionary biologists, chemical ecologists, protein biochemists, and microscopists.” Evolutionary Innovations and Species Radiation Retracing the molecular steps in gland evolution, the team identified a major evolutionary innovation in the way the beetles evolved to safely manufacture the poisonous benzoquinones. They found that rove beetles hit upon a mechanism of toxin secretion that is strikingly similar to how plants control the release of chemical compounds that deter herbivores. They bind the toxin to a sugar molecule, rendering it inactive, and then cleave the toxin from the sugar only when the chemical is secreted safely outside of the beetle’s own cells. “It’s pretty remarkable that chemically-defended beetles stitched together pretty much the same cellular mechanism as plants for not poisoning themselves with their own nasty chemicals,” says Parker. This mechanism evolved in the Early Cretaceous; after they evolved it, the beetles started to radiate into tens or possibly hundreds of thousands of species. “It’s the archetypal key innovation. Once they hit upon this solution, it really took them places, evolutionarily speaking,” Parker says. Related rove beetle lineages that lack the gland have not had the same evolutionary diversification, numbering only tens to hundreds of species. Chemical Evolution and Ecological Adaptation By exploring the chemistries of different species, the researchers found that, remarkably, while the two cell types comprising the gland have stayed largely the same, the chemicals they produce can evolve dramatically, adapting rove beetles to different ecological niches. The gland can be thought of as a kind of chemical laboratory in which a beetle species can synthesize the compounds needed to live in new environments. For example, one group of rove beetles evolved to prey on mites and repurposed the gland to secrete mite sex pheromones; another lives inside ant colonies, and produces chemicals that pacify the otherwise highly aggressive worker ants, enabling the beetle to live symbiotically with the ants, and even prey upon them. “The rove beetle tergal gland is this incredible, reprogrammable device for making new chemistries and evolving new interactions,” says Parker. “It enabled these beetles to achieve extreme forms of ecological specialization. Without the gland, there would have been no getting into the weird and wonderful niches that these beetles have found themselves.” The Irony of Evolutionary Adaptations Ironically, the team found that in one beetle group, the gland was surplus to requirements. According to Kitchen, “Apparently, once you have lived inside an army ant colony of millions of aggressive ants for long enough, you no longer need the gland. We found that beetles that have managed to trick ants into accepting them into their societies had lost their glands during evolution. Their gland toolkit genes had accumulated lots of inactivating mutations. An ant colony is a terrifying place for most species, but for these beetles it’s a danger-free fortress — they’ve conned the ants into protecting them instead.” The new study highlights how evolutionary changes at the cellular level can have major, long-term consequences for ecological and evolutionary diversification. In this case, contributing to nature’s inordinate fondness for beetles. Reference: “The genomic and cellular basis of biosynthetic innovation in rove beetles” by Sheila A. Kitchen, Thomas H. Naragon, Adrian Brückner, Mark S. Ladinsky, Sofia A. Quinodoz, Jean M. Badroos, Joani W. Viliunas, Yuriko Kishi, Julian M. Wagner, David R. Miller, Mina Yousefelahiyeh, Igor A. Antoshechkin, K. Taro Eldredge, Stacy Pirro, Mitchell Guttman, Steven R. Davis, Matthew L. Aardema and Joseph Parker, 17 June 2024, Cell. DOI: 10.1016/j.cell.2024.05.012 In addition to Kitchen and Parker, Caltech coauthors are graduate students Thomas Naragon, Jean Badroos, Joani Viliunas, Yuriko Kishi, and Julian Wagner (PhD ’24); former postdoctoral scholar Adrian Brückner; electron microscopy scientist Mark Ladinsky; former graduate students Sofia Quinodoz (PhD ’20) and David Miller (PhD ’22); former lab manager Mina Yousefelahiyeh; Director of the Caltech Genomics Facility Igor Antoshechkin; and Professor of Biology Mitch Guttman. Additional co-authors are K. Taro Eldredge of the University of Michigan, Stacy Pirro of Iridian Genomes, Steven Davis of the American Museum of Natural History, and Matthew Aardema of Montclair State University. Funding was provided by Caltech’s Center for Evolutionary Science, the Life Sciences Research Foundation, the National Science Foundation, the National Institutes of Health, the Shurl and Kay Curci Foundation, Rita Allen Foundation Scholarship, Pew Biomedical Scholarship, Alfred P. Sloan Fellowship, Iridian Genomes, Caltech’s Millard and Muriel Jacobs Genetics and Genomics Laboratory, and the American Museum of Natural History. Parker is an affiliated faculty member with the Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech.
UC San Diego researchers introduce Multi-Scale Integrated Cell (MuSIC), a technique that combines microscopy, biochemistry and artificial intelligence, revealing previously unknown cell components that may provide new clues to human development and disease. (Artist’s conceptual rendering.) Credit: UC San Diego Health Sciences Artificial intelligence-based technique reveals previously unknown cell components that may provide new clues to human development and disease. Most human diseases can be traced to malfunctioning parts of a cell — a tumor is able to grow because a gene wasn’t accurately translated into a particular protein or a metabolic disease arises because mitochondria aren’t firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts. By combining microscopy, biochemistry techniques, and artificial intelligence, researchers at University of California San Diego School of Medicine and collaborators have taken what they think may turn out to be a significant leap forward in the understanding of human cells. The technique, known as Multi-Scale Integrated Cell (MuSIC), is described on November 24, 2021, in Nature. “If you imagine a cell, you probably picture the colorful diagram in your cell biology textbook, with mitochondria, endoplasmic reticulum, and nucleus. But is that the whole story? Definitely not,” said Trey Ideker, PhD, professor at UC San Diego School of Medicine and Moores Cancer Center. “Scientists have long realized there’s more that we don’t know than we know, but now we finally have a way to look deeper.” Ideker led the study with Emma Lundberg, PhD, of KTH Royal Institute of Technology in Stockholm, Sweden and Stanford University. Left: Classic textbook cell diagrams imply all parts are clearly visible and defined. (Credit: OpenStax/Wikimedia). Right: A new cell map generated by MuSIC technic reveals many novel components. Gold nodes represent known cell components, purple nodes represent new components. The size of the node reflects a number of distinct proteins in that component. Credit: UC San Diego Health Sciences In the pilot study, MuSIC revealed approximately 70 components contained within a human kidney cell line, half of which had never been seen before. In one example, the researchers spotted a group of proteins forming an unfamiliar structure. Working with UC San Diego colleague Gene Yeo, PhD, they eventually determined the structure to be a new complex of proteins that binds RNA. The complex is likely involved in splicing, an important cellular event that enables the translation of genes to proteins, and helps determine which genes are activated at which times. The insides of cells — and the many proteins found there — are typically studied using one of two techniques: microscope imaging or biophysical association. With imaging, researchers add fluorescent tags of various colors to proteins of interest and track their movements and associations across the microscope’s field of view. To look at biophysical associations, researchers might use an antibody specific to a protein to pull it out of the cell and see what else is attached to it. The team has been interested in mapping the inner workings of cells for many years. What’s different about MuSIC is the use of deep learning to map the cell directly from cellular microscopy images. “The combination of these technologies is unique and powerful because it’s the first time measurements at vastly different scales have been brought together,” said study first author Yue Qin, a Bioinformatics and Systems Biology graduate student in Ideker’s lab. Microscopes allow scientists to see down to the level of a single micron, about the size of some organelles, such as mitochondria. Smaller elements, such as individual proteins and protein complexes, can’t be seen through a microscope. Biochemistry techniques, which start with a single protein, allow scientists to get down to the nanometer scale. (A nanometer is one-billionth of a meter, or 1/1,000th of a micron.) “But how do you bridge that gap from nanometer to micron scale? That has long been a big hurdle in the biological sciences,” said Ideker, who is also the founder of the UC Cancer Cell Map Initiative and the UC San Diego Center for Computational Biology and Bioinformatics. “Turns out you can do it with artificial intelligence — looking at data from multiple sources and asking the system to assemble it into a model of a cell.” The team trained the MuSIC artificial intelligence platform to look at all the data and construct a model of the cell. The system doesn’t yet map the cell contents to specific locations, like a textbook diagram, in part because their locations aren’t necessarily fixed. Instead, component locations are fluid and change depending on cell type and situation. Ideker noted this was a pilot study to test MuSIC. They’ve only looked at 661 proteins and one cell type. “The clear next step is to blow through the entire human cell,” Ideker said, “and then move to different cell types, people, and species. Eventually, we might be able to better understand the molecular basis of many diseases by comparing what’s different between healthy and diseased cells.” Reference: “A multi-scale map of cell structure fusing protein images and interactions” by Yue Qin, Edward L. Huttlin, Casper F. Winsnes, Maya L. Gosztyla, Ludivine Wacheul, Marcus R. Kelly, Steven M. Blue, Fan Zheng, Michael Chen, Leah V. Schaffer, Katherine Licon, Anna Bäckström, Laura Pontano Vaites, John J. Lee, Wei Ouyang, Sophie N. Liu, Tian Zhang, Erica Silva, Jisoo Park, Adriana Pitea, Jason F. Kreisberg, Steven P. Gygi, Jianzhu Ma, J. Wade Harper, Gene W. Yeo, Denis L. J. Lafontaine, Emma Lundberg and Trey Ideker, 24 November 2021, Nature. DOI: 10.1038/s41586-021-04115-9 Co-authors include: Maya L. Gosztyla, Marcus R. Kelly, Steven M. Blue, Fan Zheng, Michael Chen, Leah V. Schaffer, Katherine Licon, John J. Lee, Sophie N. Liu, Erica Silva, Jisoo Park, Adriana Pitea, Jason F. Kreisberg, UC San Diego; Edward L. Huttlin, Laura Pontano Vaites, Tian Zhang, Steven P. Gygi, J. Wade Harper, Harvard Medical School; Casper F. Winsnes, Anna Bäckström, Wei Ouyang, KTH Royal Institute of Technology; Ludivine Wacheul, Denis L. J. Lafontaine, Université Libre de Bruxelles; and Jianzhu Ma, Peking University. Funding for this research came, in part, from the National Institutes of Health (grants U54CA209891, U01MH115747, F99CA264422, P41GM103504, R01HG009979, U24HG006673, U41HG009889, R01HL137223, R01HG004659, R50CA243885), Google Ventures, Erling-Persson Family Foundation, Knut and Alice Wallenberg Foundation (grant 2016.0204), Swedish Research Council (grant 2017-05327), Belgian Fonds de la Recherche Scientifique, Université Libre de Bruxelles, European Joint Programme on Rare Diseases, Région Wallonne, Internationale Brachet Stiftung, and Epitran COST action (grant CA16120). Disclosures: Trey Ideker is co-founder of, on the Scientific Advisory Board and has an equity interest in Data4Cure, Inc. Ideker is also on the Scientific Advisory Board, has an equity interest in and receives sponsored research funding from Ideaya BioSciences, Inc. Gene Yeo is a co-founder, member of the Board of Directors, on the Scientific Advisory Board, an equity holder and a paid consultant for Locanabio and Eclipse BioInnovations. Yeo is also a visiting professor at the National University of Singapore. The terms of these arrangements have been reviewed and approved by the University of California San Diego in accordance with its conflict-of-interest policies. Emma Lundberg is on the Scientific Advisory Boards of and has equity interests in Cartography Biosciences, Nautilus Biotechnology and Interline Therapeutics. J. Wade Harper is a co-founder of, on the Scientific Advisory Board and has an equity interest in Caraway Therapeutics. Harper is also Founding Scientific Advisor for Interline Therapeutics.
Heterochromatin enrichment across chromosomes. Immunofluorescence staining for H3K9me3 in male mitotic chromosomes. Scale bar is 50μm. Credit: Nguyen AH et al., 2021, PLOS Genetics DNA repeats on the Y chromosome become more active and toxic as male flies age. Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published today (April 22, 20210 in PLOS Genetics. In humans and other species with XY sex chromosomes, females often live longer than males. One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a “toxic y effect” that shortens males’ lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as females and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in toxic side effects. The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in fruit flies have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging’s physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA’s toxic effects. Reference: “Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome” by Alison H. Nguyen and Doris Bachtrog, 22 April 2021, PLOS Genetics. DOI: 10.1371/journal.pgen.1009438 Funding: This work was supported by NIH grants (nos. R01GM076007, R01GM101255 and R01AG057029) to DB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DVDV1551RTWW78V
Indonesia eco-friendly graphene material processing 》recommended by industry experts for sustainability and performanceVietnam ergonomic pillow OEM supplier 》experience you can count on, quality you can trustChina athletic insole OEM supplier 》from raw material to finished product,we do it all