Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw
Taiwan graphene sports insole ODM
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan insole ODM manufacturing factory for global brands
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand custom neck pillow ODM
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia custom product OEM/ODM services
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.PU insole OEM production in China
Researchers at MIT have identified a vast array of Fanzors, programmable DNA-cutting enzymes from eukaryotic organisms, expanding the gene-editing potential of RNA-guided tools and opening up possibilities for more precise and efficient genome modifications, particularly in human cells. New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms. A diverse set of species, from snails to algae to amoebas, make programmable DNA-cutting enzymes called Fanzors — and a new study from scientists at MIT’s McGovern Institute for Brain Research has identified thousands of them. Fanzors are RNA-guided enzymes that can be programmed to cut DNA at specific sites, much like the bacterial enzymes that power the widely used gene-editing system known as CRISPR. The newly recognized diversity of natural Fanzor enzymes, reported recently in the journal Science Advances, gives scientists an extensive set of programmable enzymes that might be adapted into new tools for research or medicine. “RNA-guided biology is what lets you make programmable tools that are really easy to use. So the more we can find, the better,” says McGovern Fellow Omar Abudayyeh, who led the research with McGovern Fellow Jonathan Gootenberg. CRISPR and the Promise of Fanzors CRISPR, an ancient bacterial defense system, has made it clear how useful RNA-guided enzymes can be when they are adapted for use in the lab. CRISPR-based genome editing tools developed by MIT professor and McGovern investigator Feng Zhang, Abudayyeh, Gootenberg, and others have changed the way scientists modify DNA, accelerating research and enabling the development of many experimental gene therapies. Amoeba proteus. Researchers have since uncovered other RNA-guide enzymes throughout the bacterial world, many with features that make them valuable in the lab. The discovery of Fanzors, whose ability to cut DNA in an RNA-guided manner was reported by Zhang’s group earlier this year, opens a new frontier of RNA-guided biology. Fanzors were the first such enzymes to be found in eukaryotic organisms — a wide group of lifeforms, including plants, animals, and fungi, defined by the membrane-bound nucleus that holds each cell’s genetic material. (Bacteria, which lack nuclei, belong to a group known as prokaryotes.) “People have been searching for interesting tools in prokaryotic systems for a long time, and I think that that has been incredibly fruitful,” says Gootenberg. “Eukaryotic systems are really just a whole new kind of playground to work in.” One hope, Abudayyeh and Gootenberg say, is that enzymes that naturally evolved in eukaryotic organisms might be better suited to function safely and efficiently in the cells of other eukaryotic organisms, including humans. Zhang’s group has shown that Fanzor enzymes can be engineered to precisely cut specific DNA sequences in human cells. In the new work, Abudayyeh and Gootenberg discovered that some Fanzors can target DNA sequences in human cells even without optimization. “The fact that they work quite efficiently in mammalian cells was really fantastic to see,” Gootenberg says. Evolutionary Insights and Future Applications Prior to the current study, hundreds of Fanzors had been found among eukaryotic organisms. Through an extensive search of genetic databases led by lab member Justin Lim, Gootenberg and Abudayyeh’s team has now expanded the known diversity of these enzymes by an order of magnitude. Among the more than 3,600 Fanzors that the team found in eukaryotes and the viruses that infect them, the researchers were able to identify five different families of the enzymes. By comparing these enzymes’ precise makeup, they found evidence of a long evolutionary history. Fanzors likely evolved from RNA-guided DNA-cutting bacterial enzymes called TnpBs. In fact, it was Fanzors’ genetic similarities to these bacterial enzymes that first caught the attention of both Zhang’s group and Gootenberg and Abudayyeh’s team. The evolutionary connections that Gootenberg and Abudayyeh traced suggest that these bacterial predecessors of Fanzors probably entered eukaryotic cells, initiating their evolution, more than once. Some were likely transmitted by viruses, while others may have been introduced by symbiotic bacteria. The research also suggests that after they were taken up by eukaryotes, the enzymes evolved features suited to their new environment, such as a signal that allows them to enter a cell nucleus, where they have access to DNA. Through genetic and biochemical experiments led by biological engineering graduate student Kaiyi Jiang, the team determined that Fanzors have evolved a DNA-cutting active site that is distinct from that of their bacterial predecessors. This seems to allow the enzyme to cut its target sequence more precisely the ancestors of TnpB, when targeted to a sequence of DNA in a test tube, become activated and cut other sequences in the tube; Fanzors lack this promiscuous activity. When they used an RNA guide to direct the enzymes to cut specific sites in the genome of human cells, they found that certain Fanzors were able to cut these target sequences with about 10 to 20 percent efficiency. With further research, Abudayyeh and Gootenberg hope that a variety of sophisticated genome editing tools can be developed from Fanzors. “It’s a new platform, and they have many capabilities,” says Gootenberg. “Opening up the whole eukaryotic world to these types of RNA-guided systems is going to give us a lot to work on,” Abudayyeh adds. Reference: “Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses” by Kaiyi Jiang, Justin Lim, Samantha Sgrizzi, Michael Trinh, Alisan Kayabolen, Natalya Yutin, Weidong Bao, Kazuki Kato, Eugene V. Koonin, Jonathan S. Gootenberg and Omar O. Abudayyeh, 27 September 2023, Science Advances. DOI: 10.1126/sciadv.adk0171
New research has revealed that the brain and testes appear to be extremely adaptable to the use of many different kinds of genetic code to produce a given protein. Rare Pieces of Genetic Code May Serve As Another Way To Control Cellular Machinery A new investigation into the way different tissues read information from genes has discovered that the brain and testes appear to be extraordinarily open to the use of many different kinds of code to produce a given protein. In fact, the testes of both fruit flies and humans seem to be enriched in protein products of these rarely-used pieces of genetic code. According to the researchers, the utilization of rare pieces of code may be another layer of control in the genome that could be essential to fertility and evolutionary innovation. A decade after solving the structure of DNA as a double helix of the bases A, C, T, and G, Francis Crick went on to decode the intermediate step by which three of these letters are translated into a “codon,” the recipe for a single amino acid. Amino acids are the building blocks of protein. What was striking at the time and still somewhat puzzling is that this layer of life’s code used 61 different three-letter codons to produce just 20 amino acids, meaning many codons were being used to describe the same thing. The Role of Rare Codons in Different Tissues “We’re taught in our biology classes that when you change from one version of the codon to the other, and it doesn’t change the amino acid, that’s called a silent mutation. And that implies that it doesn’t matter,” said Don Fox, an associate professor of pharmacology and cancer biology in the Duke School of Medicine. “Yet when researchers have sequenced all these different organisms, they found a hierarchy,” Fox said. “Some codons are really frequent and some are really rare.” And that distribution of codons can vary from one kind of tissue in an organism to another. A translucent fruit fly larvae glows where a green fluorescent protein (GFP) is being expressed by codons that are rare in the fly genome. Only two tissues, the brain (left) and testis (right) are capable of expressing this version of GFP. Credit: Fox Lab, Duke University Fox wondered if the rarities play a role in how, say, a liver cell does liver things and how a bone cell does bone things. Exploring Tissue-Specific Codon Bias Fox and his team, headed by PhD student Scott Allen, wanted to zoom in on the rare codons, using their preferred model Drosophila melanogaster, the laboratory fruit fly. A growing body of work has shown that dissimilar tissues have varying ‘codon bias’ — that is, different frequencies of synonymous codons occurring in different tissues. Rare codons are known to slow down and even stop protein production and “genes with a lot of these rare codons make a lot less protein,” Fox said. Fox was collaborating with colleague Christopher Counter, the George Barth Geller Distinguished Professor of Pharmacology at Duke to understand a gene called KRAS, which is known to be a bad actor in pancreatic cancer especially, and which carries a lot of rare codons. Why, they wondered, would a cancer mutation have slowed down protein production, when normally a cancerous mutation makes more of something. “It turns out, the way KRAS is designed, it should be very hard to make any of it,” Fox said. Fox’s team developed a new way of analyzing tissue-specific codon usage to look at where and how rare codons can be used in the fruit fly, which has perhaps the best-known genome in science. They ran a series of experiments to vary which codons were included in the KRAS gene and found that rare codons had a dramatic effect on how KRAS controls signaling between cells. “I realized from this cancer collaboration that we could take similar approaches and apply them to my primary research question, which is how tissues know what they are,” Fox said. In further experiments, they found that testes in flies — and in humans — are more tolerant of a high diversity of codons, but fly ovaries are not. The fly brain was also more tolerant of diverse codons. The work was published on May 6, 2022, in the open-access journal eLife. Rare Codons: Fertility and Evolutionary Innovation One particular gene with a high number of rare codons, RpL10Aa, is evolutionarily newer and helps to build the ribosome, the protein-assembly machinery in the cell. Fox said it appears that this gene’s rare codons serve to limit its activity to just the more tolerant testes, and that, in turn, maybe something critical to fertility. “The way the testes seem to permit almost any gene being expressed, perhaps that makes it a breeding ground, if you will, for new genes,” Fox said. “The testes seem to be a place where younger genes tend to first be expressed. So we think it’s sort of this more permissive tissue, and it lets new genes take hold.” “What we think we’re seeing is that rare codons are a way to limit the activity of this evolutionarily young gene to the testes,” Fox said. “That would make rare codons yet another layer of control and fine-tuning in the genes.” The editors of eLife said, “The work breaks new ground in identifying codon usage as a basis for tissue-specific gene expression in animals.” Reference: “Distinct responses to rare codons in select Drosophila tissues” by Scott R Allen, Rebeccah K Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M Counter, Jessica K Sawyer, Donald T Fox, 6 May 2022, eLife. DOI: 10.7554/eLife.76893 This research was supported by the American Cancer Society, (RSG-128945) the National Science Foundation, and the National Institutes of Health (R01-CA94184, P01-CA203657, R35-GM140844, R01-HL111527)
Venomous Caterpillar Doratifera vulnerans The venom of a caterpillar, native to South East Queensland, shows promise for use in medicines and pest control, Institute for Molecular Bioscience researchers say. The Doratifera vulnerans is common to large parts of Queensland’s south-east and is routinely found in Toohey Forest Park on Brisbane’s southside. Dr. Andrew Walker has been researching the striking-looking caterpillar since 2017. The Doratifera vulnerans is common to large parts of Queensland’s south-east and shows promise for use in medicines and pest control, Institute for Molecular Bioscience researchers say. Credit: Institute for Molecular Bioscience, The University of Queensland Venomous caterpillar has strange biology “We found one while collecting assassin bugs near Toowoomba and its strange biology and pain-causing venom fascinated me,” Dr. Walker said. Unlike The Very Hungry Caterpillar that charmed generations of children around the world, this caterpillar is far from harmless. “Its binomial name means ‘bearer of gifts of wounds’,” Dr. Walker said. The caterpillar has spines that inject liquid venom. Credit: Jiayi Jin Caterpillar venom similar to spiders Dr. Walker’s research found the caterpillar has venom toxins with a molecular structure similar to those produced by spiders, wasps, bees, and ants. The research also unlocked a source of bioactive peptides that may have uses in medicine, biotechnology, or as scientific tools. “Many caterpillars produce pain-inducing venoms and have evolved biological defenses such as irritative hairs, toxins that render them poisonous to eat, spots that mimic snake eyes or spines that inject liquid venoms,” Dr. Walker said. “Previously researchers had no idea what was in the venom or how they induce pain. Venom with stunning complexity “We found that the venom is mostly peptides and shows stunning complexity, containing 151 different protein-based toxins from 59 different families.” The research team synthesized 13 of the peptide toxins and used them to show the unique evolutionary trajectory the caterpillar followed to produce pain-inducing venom. “We now know the amino acid sequences, or the blueprints, of each protein-based toxin,” Dr Walker said. “This will enable us to make the toxins and test them in diverse ways.” Venom can kill bacteria Some peptides already produced in the laboratory as part of Dr. Walker’s research showed very high potency, with the potential to efficiently kill nematode parasites that are harmful to livestock, as well as disease-causing pathogens. “Our research unlocks a new source of bioactive peptides that may have use in medicine, through an ability to influence biological processes and promote good health,” he said. Potential for medicines and pesticides “First, we need to work out what the individual toxins do, to inform us about how they might be used.” The findings incorporate work from researchers at the CSIRO, Canada’s York University, Austria’s University of Vienna, and the Department of Food and Agriculture in the US. The research is published in the Proceedings of the National Academy of Sciences of the USA. Reference: “Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans” by Andrew A. Walker, Samuel D. Robinson, Jean-Paul V. Paluzzi, David J. Merritt, Samantha A. Nixon, Christina I. Schroeder, Jiayi Jin, Mohaddeseh Hedayati Goudarzi, Andrew C. Kotze, Zoltan Dekan, Andy Sombke, Paul F. Alewood, Bryan G. Fry, Marc E. Epstein, Irina Vetter, and Glenn F. King, 22 June 2021, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2023815118
DVDV1551RTWW78V
Thailand insole ODM design and production 》supporting your ESG goals through sustainable productionESG-compliant OEM/ODM production factory in Taiwan 》helping your business stand out with material and functional innovationTaiwan insole OEM manufacturing factory 》experience you can count on, quality you can trust